Haemoglobinopathy screen


Alternative names, keywords

Hb'opathy, HbA2, HbF quantitation, HbS, HbC, beta thalassaemia.

Samples required

EDTA blood (purple cap/ black cap ring, 4 mL tube). Smaller tubes are available for paediatric samples.

Test indications

For investigation of haemoglobinopathies e.g HbS, HbC, beta thalassaemia.

Reference range

Haemoglobin HbA2: 2.0 - 3.2 %
Haemoglobin F (adults): ≤ 1.0 %

Source: ranges determined in-house.

Samples are referred by Haematology Department after initial investigation for confirmation of haemoglobinopathy / thalassaemia by HPLC or molecular analysis.

2 x 4 mL EDTA blood required.

Referred to Red Cell Protein Laboratory, Haematology Department, King's College Hospital, London SE5 9RS, or National Haemoglobinopathy Reference Centre, Haematology Laboratory, John Radcliffe Hospital, Headington, Oxford OX3 9DU

Turnaround time: 4-6 weeks

Turnaround time

3 working days (unless Hb variant found).