Intrinsic factor antibody


Alternative names, keywords

IFA, gastric parietal cell antibody, pernicious anaemia.

Samples required

Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Test indications

Investigation of pernicious anaemia.

Test information

Immunoassay for intrinsic factor. Positive results have high specificity for pernicious anaemia, but the sensitivity of the assay is fairly low at around 60%.

Please note that gastric parietal cell antibodies have very poor diagnostic value due to low specificity and are no longer offered. Requests will be substituted for intrinsic factor antibody where appropriate.

Method: Phadia 250 ELIA

Reference range

Reported as negative, weak positive or positive.

Turnaround time

14 days.