GBM antibody


Alternative names, keywords

Glomerular basement membrane antibody, anti GBM.

Samples required

Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Test indications

Acute renal failure, acute pulmonary haemorrhage. Also used for monitoring disease activity in known patients.

Test information

Positive results have strong predictive value for rapidly progressive glomerulonephritis (anti GBM disease, Goodpasture’s) and alveolitis.  Some patients with ANCA-associated vasculitis also have positive GBM antibodies.

Method: Phadia 250 ELIA

Reference range

Negative < 7 U/mL
Equivocal 7-10 U/mL
Positive ≥ 10 U/mL

Turnaround time

3 days.

Urgent analysis is available on request during routine hours.  For same-day results, the sample should be received by 12pm and the laboratory must be notified.