Referred to Berkshire & Surrey Pathology Services, Frimley Park Hospital NHS Foundation Trust, Portsmouth Road, Frimley, Surrey GU16 7UJ

Alternative names, keywords

Procollagen type 1 N-terminal propeptide, procollagen 1, procollagen extension peptide, amino pro-peptide of type 1 collagen.

Samples required

Clotted blood (gold cap, 5 mL tube).

Note change in sample type from October 2020 due to a change in provider at the referral laboratory - EDTA plasma is no longer accepted .

Test indications

Marker of bone formation.

Reference range

Adult female (pre-menopausal): 30 - 78 µg/L
Adult female (post-menopausal): 26 - 110 µg/L
Adult male: 20 - 76 µg/L

Bisphosphonate monitoring

Baseline: > 80 µg/L - seek cause of high bone turnover.
Response at 6 months:
Good: < 35 µg/L and/or fall >10 µg/L
Suboptimal: > 35 g/L and fall <10 µg/L

Note change in reference ranges from September 2020 due to a change in provider at the referral laboratory.


Turnaround time

Referral lab quotes turnaround time of 15 days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.


Biochemistry (Referrals)