AMH

 

Alternative names, keywords

Anti-Müllerian Hormone

Samples required

Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Test indications

Assessment of ovarian reserve.

Can also be used in investigations of disorders of sexual development - these samples are referred.

Factors affecting test performance/ results

Biotin may interfere - samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration.

In rare cases, interference due to extremely high titres of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur.

Results should always be assessed in conjunction with the patient’s medical history, clinical examination and other findings.

Reference range

    AMH (pmol/L)*
Females (not taking oral contraception) 20 to 24 years 8.7 - 83.6
25 to 29 years 6.4 - 70.3
30 to 34 years 4.1 - 58.0
35 to 39 years 1.1 - 53.5
40 to 44 years 0.2 to 39.1
45 to 50 years 0.1 to 19.3

Males

  5.5 - 103
* 2.5th to 97.5th percentile

Source: Roche Cobas® AMH kit insert, 2016-11 V 1.0

 

Use of AMH for assessment of ovarian reserve

AMH range Antral follicle count  
less than 4.9 pmol/L 0 - 7 Low responders
4.9 - 16.2 pmol/L 8 - 15 Normal responders
greater than 16.2 pmol/L > 15 High responders

 

NHS funding for fertility treatment by Brighton & Hove CCG is considered if AMH > 4.9 pmol/L. Do not repeat within 1 year.

Turnaround time

Four working days

Enquiries

Biochemistry (Automation PRH)