Metadrenalines (urine)

Referred to Berkshire & Surrey Pathology Services, Frimley Park Hospital NHS Foundation Trust, Portsmouth Road, Frimley, Surrey GU16 7UJ

Alternative names, keywords

Normetadrenaline, metadrenaline, 3-methoxytyramine, metanephrines, normetanephrine

Samples required

24h urine collection - click here for printable instructions

24 hour urine collection in acidified container.

Please avoid the following for the 24 hours of the collection: vigorous exercise, excess nicotine (smoking, nicotine patches, electronic cigarettes), coffee, large doses of vitamin C, curry leaves and chili pepper (capsaicin). Click here for printable list.

Medications can also affect the results.  Please list any medications on the request form.

Random urine for paediatrics - take to lab immediately for acidification).

Note that a single 24h collection is required; there is no need to do 3x 24h collections.

Test indications

First line test for investigation of ?sporadic phaeochromocytoma or paraganglioma. Click for protocols for investigation of suspected sporadic phaeochromocytoma:

in primary care

in secondary care

Reference range


< 3.3 µmol/24h


< 1.2 µmol/24h


< 2.5 µmol/24h

Age-related ranges apply to random paediatric samples - see report.

Turnaround time

Referral lab quotes turnaround time of 10 days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.


Biochemistry (Referrals)