Cholinesterase (serum)

Referred to Berkshire & Surrey Pathology Services, Frimley Park Hospital NHS Foundation Trust, Portsmouth Road, Frimley, Surrey GU16 7UJ

Alternative names, keywords

Pseudocholinesterase, butyrylcholinesterase, scoline apnoea, cholinesterase phenotype, dibucaine number, fluoride number, Ro 02-0683 number.

Samples required

Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Avoid sampling after recent blood transfusion, do not collect during scoline apnoea.

Test indications

For scoline apnoea and family studies of patients with cholinesterase deficiency. Cholinesterase deficiency will result in prolonged paralysis after the use of muscle relaxants for operative surgery.

For organophosporous exposure request red cell acetylcholinesterase.

Reference range

Cholinesterase activity 650 - 1450 U/L

Remember to test the first degree relatives of those affected - especially siblings.

Turnaround time

Referral lab quotes turnaround time of 12 days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.


Biochemistry (Referrals)